Some women have contraindications to HRT. This means that they have conditions which may be worsened by taking it. There are not many, but they are fairly important. It has been recommended that women who have had proven breast or endometrial (lining of the uterus) cancers should not have HRT. This is because these particular cancers can be hormone sensitive, so oestrogen may accelerate their growth.
Women who have certain liver diseases are advised against taking oestrogen. Progesterone alone is sometimes used to help control symptoms in women who cannot take oestrogen.
The side-effects of HRT. Women do quite often experience some side-effects, particularly when starting HRT a few years after menopause. The most common oestrogen-related ones include breast and nipple tenderness, nausea, headache, leg cramps, bloating and fluid retention, and weight gain (usually 1 or 2 kilograms, sometimes more in women who are overweight to begin with). The progesterone component can give similar symptoms, and a premenstrual syndrome feeling during the time it is being taken. Most of these symptoms subside within a couple of months, and may also be alleviated by a dose adjustment.
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