WOMEN’S HEALTH: HORMONE REPLACEMENT THERAPY (HRT)
Saturday, June 25th, 2011HRT has been seen as a universal panacea, a solution to all menopausal problems from osteoporosis to ageing skin. It has been pushed by the media and is supposed to give us the energy of a spring chicken and the libido of a teenager. The principle behind HRT is that it supplies us with hormones when our own production slows down. Thus we can avoid the hot flushes, the night sweats and many of the other ‘symptoms’ of the menopause with the medical equivalent of one-stop shopping. Dr Ellen Grant, who wrote The Bitter Pill, suggests that HRT, which delivers a constant level of oestrogen, is like having a car stuck in a single gear. Surely it is better to let our own pituitary gland and ovaries work together to make fine adjustments constantly for our hormone needs at each moment, like a car with automatic gears? Given optimum health, our hormones are able to balance themselves. Our bodies are able to make the judgment on whether we have too much of one hormone, or need to produce more of another: just like a central heating thermostat, which will switch on the boiler if the room temperature drops and turn it off again when the room heats up.
Oestrogen therapy has been around since the 1930s when injections of oestrogen were given for menopausal symptoms. Because of the inconvenience of this form of treatment, implant pellets of oestrogen were introduced in 1938. HRT was originally called Oestrogen Replacement Therapy because only oestrogen was given as the treatment. However, it became clear that giving oestrogen alone could increase the risk of cancer of the womb and breasts. When research studies appeared to demonstrate that this increased risk could be up to seven times higher for womb cancer, there was panic. Oestrogen therapy declined sharply in popularity. Then progestogen, the synthetic version of progesterone, was added to the therapy for ten to fourteen days each month and HRT, using both hormone drugs, was re-marketed. Since then there seems to be no end to what HRT can do for us. There is always something new. Over the last year, I have seen newspaper reports that HRT might help patients with ME, inflammatory bowel disease, post-natal depression, pre-menstrual migraine – and prevent Alzheimer’s disease. An opera singer found that it had a wonderful effect on her voice. Most of us are much more interested in just what the risks of HRT really are. The main reasons for the addition of progestogen to HRT are to protect the womb lining from over-stimulation and subsequent cancer, and to cause a regular bleed. Women who have had a hysterectomy obviously cannot get womb cancer so they are not given progestogen.
It is important to make clear the difference between progesterone (our own naturally occurring hormone) and progestogen (the synthetic hormone in the Pill and HRT). Many people, even doctors, treat them as the same thing and they are not. Progesterone is made just prior to ovulation by the corpus luteum and is the major female hormone for the second half of the menstrual cycle. It is absolutely necessary to maintain a pregnancy. As progesterone raises at ovulation our body temperature rises ready to ‘incubate’ the fertilized egg. If we are pregnant, progesterone continues to rise. If we are not pregnant, both oestrogen and progesterone levels fall and we have a period. If a woman does not produce sufficient progesterone when the egg is fertilized, she can miscarry.
Progestogens, on the other hand, are synthetic. Though they are able to fulfill many of progesterone’s functions, the human body has difficulty ‘recognizing’ and coping with progestogens because they are not natural, hence the well-known side effects such as mood swings, depression, etc. These synthetic progestogens are used for their progesterone-like action but they can have additional male or female hormone effects. So one type of progestogen may cause enlargement of the breasts, while another can increase the growth of facial hair. All somewhat alarming.
*9/101/5*